Small animals phenotyping and imaging core (Animal)
Name of entity
Small animals phenotyping and imaging core
Entity type
Plateform
Keywords
Beta cells, pancreatic islets, insulin secretion, glucose metamolism, clamps, energy balance, animal models of diabetes (type 1 et 2) obesity. Arterial pressure, cardiac function, body composition, imagery, micro-CT, Skyscan1176, ART Optix MX2, EchoMRI Analyzer-700, telemetry, surgical services
Area of expertise
We perform routine tolerance tests (glucose, lipids, pyruvate, insulin) and indirect calorimetry in metabolic cages, as well as several imaging and telemetry services in rodents (temperature, blood pressure).
The core facility also has exceptional expertise in performing hyperglycaemic clamps and hyperinsulinaemic clamps, which are more informative than tolerance tests.
Services offered
We offer our services to researchers from universities, hospitals, and industrial sectors.
Offered services : The areas of expertise of the platform are as follows:
Research projects at cellular, tissue and animal levels
Complete metabolic phenotyping of genetically modified rodents
Evaluation of the effect of pharmacological or molecular interventions on carbohydrate and/or energy metabolism in healthy rodent models, obesity and/or diabetes models.
Housing in metabolic cages for indirect calorimetry as well as urine and faeces collection.
Telemetry
Surgical services
Probe implantation
Renal ischemia/reperfusion models
Many others
Imaging services
Fluorescence and bioluminescence (IVIS spectrum, ART Optix MX2)
Body composition (EchoMRI)
MicroCT (SkyScan 1176)
etc.
All surgeries, metabolic tests, assays, and data analysis are carried out entirely by our own staff.
Responsable
Khalil Bouyakdan
phenotypage.cr.chum@ssss.gouv.qc.ca
Address
Full address : CRCHUM-Tour Viger
900 rue St-Denis
Montreal QC H2X0A9